While OpenPose focuses specifically on human pose estimation, MediaPipe provides a broader array of pre-built solutions with higher accuracy, better optimisation for on-device performance, and more extensive platform support, making it a more versatile and efficient choice for various applications.

Focus: OpenPose specialises in human pose estimation with high accuracy, while MediaPipe offers a wider range of pre-built solutions.

Performance: OpenPose is an old pose estimation framework with low accuracy. MediaPipe offers higher accuracy, better on-device optimisation and broader platform support.